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InChiKey: BRYXUCLEHAUSDY-WEWMWRJBSA-N
PD153035 effectively blocks the enhancement of mitogenesis
Chemical Name: methyl 3-[(21S
[Pharmacological properties of MO-8282
5-trifluorophenyl)-
SAH-SOS1A TFA Catalog No.:M16665-C InChiKey: BRYXUCLEHAUSDY-WEWMWRJBSA-NSAH SOS1A TFA is a peptide based SOS1 KRAS protein interaction inhibitor. SAH SOS1A TFA binds to wild type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106 175 nM) and directly and independently blocks nucleotide association. SAH SOS1A TFA impairs KRAS driven cancer cell viability and exerts its effects by on mechanism blockade of the ERK MAPK phosphosignaling cascade downstream of KRAS. Product information
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